Saracens' Heineken Cup home match against the Ospreys will take place at Wembley Stadium.
The Men in Black will take on the Welsh giants at the famous venue at 6pm on Saturday, December 10. The return match between the sides takes place six days later on Friday, December 16 with an 8pm kick-off.
Premiership champions Sarries begin their European campaign against Italian side Benetton Treviso at Vicarage Road on Sunday, November 13.
Saracens' first away match in this year's competition is in France when they face a daunting trip to Biarritz on Saturday, November 19.
The Men in Black have confirmed they will play at least two games at Wembley this season with their league match against Harlequins on Saturday, March 31 also taking place there.
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